Endocrine Abstracts

Exertional symptoms, dyspnea, and impaired effort tolerance are common in patients with Graves’ disease. Proposed explanations include high-output left heart failure, ineffective oxygen utilization, and respiratory muscle weakness. In addition, cases of pulmonary arterial hypertension (PAH) in patients with Graves’ disease have been reported. Vascular endothelial growth factor (VEGF) is produced by thyroid follicular epithelial cells in response to stimulation of the...

Introduction: Pneumomediastinum is a rare complication of diabetic ketoacidosis (DKA). The pathophysiology of DKA commonly associated with changes in pressure gradients in the pulmonary alveoli secondary to vomiting and/or Kussmaul respiration. We report a 21-year-old male with DKA who have no history of diabetes mellitus before and was found to have pneumomediastinum and subcutaneous emphysema.Case: A 21-year-old male without previous history of diabete...

Background and aims: To evaluate the efficacy and safety of the newly developed dipeptidyl peptidase-4 (DPP-4) inhibitor evogliptin in drug-naïve patients with inadequately controlled type 2 diabetes.Materials and methods: In randomized, double-blind, placebo-controlled, parallel-group, multicenter, phase III study, 160 patients with type 2 diabetes were randomized to evogliptin 5 mg or placebo for 24 weeks. The primary efficacy outcome measure was ...

The combination of hypoparathyroidism, sensorineural deafness and renal dysplasia, named HDR syndrome, is a rare disease. Heterozygous abnormalities of GATA3 gene are associated with this syndrome. Here we report a novel heterozygous mutation, c.255_256ins4 (GTGC), in GATA3 gene. A 41-year-old man was diagnosed as having idiopathic hypoparathyroidism and has been treated with 1α-hydroxyvitamin D3 and calcium carbonate. Three years later, he had a hearing...

Thyroxine-binding globulin (TBG), the major transport protein for thyroid hormone in circulation, is synthesized in the liver. Complete TBG deficiency was first reported in 1964, and in 1991 a single nucleotide deletion was found in the first base of the codon for amino acid 352 of the common-type TBG molecule. This mutation causes a frameshift in translation and premature termination. Most people with abnormal TBG concentrations are euthyroid. Cases of Graves’ disease wi...

Current guidelines on cardiovascular (CV) disease prevention recommend targeted management after assessment of CV risks using many of available method even if the patient is asymptomatic. This study was performed to explore how CV high-risk is differently detected between two distinct methods: non-invasive test (NIT) and risk calculation and how the awareness of CV high-risk impacts physician and patient behavior for risk management in diabetes patient.A...

Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults.Methods: In total, 51...

Aim: An international expert committee, after considering data on association of HbA1c and retinopathy, recommended that diabetes be diagnosed when HbA1c is more than 48 mmol/mol (>6.5%), provided this assay is done in a standardized laboratory. However, the performance of HbA1c in detecting diabetes in the Korean population remains unknown. The purpose of this study was to evaluate the efficiency of HbA1c in diagnosing diabetes and to identify the optimal threshold in the...

Aim: HbA1c is recommended as a diagnostic criterion for diabetes in clinical practice guidelines for type 2 diabetes in 2011 (10). Although there have been several reports that compared HbA1c-based diagnosis for diabetes with glucose-based diagnosis in Koreans, it is thought that larger epidemiological studies are required to confirm the association of HbA1c and FPG for diagnosis of diabetes for the Korean population. We conducted this study to examine the relationship between...